Arrhythmias & electrophysiology
Associations Between Changes in Maximum Daily Atrial Fibrillation Duration, Ischemic Stroke, and Mortality
Main finding · Stroke and mortalityResult — go to the resultHazard ratio 1.80 95% CI 1.61–2.01Authors' conclusion
In CIED patients not on oral anticoagulation, increased MDAFD in follow-up was associated with a higher rate of stroke and mortality.
Study context
- Population
- Patients with cardiac implantable electronic devices (CIEDs) not on oral anticoagulation, Optum EHR linked with Medtronic CareLink (2007–2021)2,544 (9.6%) atrial fibrillation (AF) at baseline
- Participants
- 26,400 patients
- Exposure
- Increased vs stable or decreased maximum daily AF duration (MDAFD) category in follow-up
- Outcome
- Stroke and mortality
Methodological detailslinked EHR and device database, MDAFD assessed 30 days post implant (baseline) and 30 days before censoring or event
- Linked EHR and device database
- MDAFD assessed 30 days post implant (baseline) and 30 days before censoring or event
Main finding
As reported in the abstract
Hazard ratio
1.80
95% CI 1.61–2.01
Increased MDAFDvs Stable or decreased MDAFD
HR 1.80 (95% CI 1.61–2.01)
Observational data: associations, not effects.
Further findings
Decreased MDAFD in follow-up, combined endpoint
| HR (95% CI) | ||
|---|---|---|
| Decreased MDAFDNo association | 0.82 (0.68–1.00) | |
| 0.512Hazard ratio (log scale) |
Stroke or mortality, by baseline MDAFD category (subgroup)
- Increased MDAFD associated with greater risk among patients with no AF at baseline
- Decreased MDAFD associated with lower risk among patients with baseline MDAFD 1 to <5.5 h and 5.5 to <23.5 h
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations Between Changes in Maximum Daily Atrial Fibrillation Duration, Ischemic Stroke, and Mortality. JACC Clin Electrophysiol. Published 21 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →