Substance Use in Pregnancy and its Association With Cardiovascular Events
Main finding · Acute CV eventsResult — go to the resultAdjusted odds ratio 1.61 95% CI 1.53–1.70Authors' conclusion
Substance use has a strong association with acute CV events and maternal mortality during hospitalization for delivery
Study context
- Population
- Women with a delivery hospitalization, US Nationwide Inpatient Sample, 2004–2018
- Participants
- 60,014,368 delivery hospitalizations
- Exposure
- Substance use vs no substance use in pregnancy
- Substance usen = 955,531
- Outcome
- Any acute CV event:
- Acute MI
- Stroke
- Arrhythmia
- Endocarditis
- Acute cardiomyopathy or HF
- Cardiac arrest
- Follow-up
- During delivery hospitalization
Methodological detailsNationwide Inpatient Sample, multivariable logistic regression
- Nationwide Inpatient Sample
- Multivariable logistic regression
Main finding
Acute CV events
Adjusted odds ratio
1.61
95% CI 1.53–1.70
P < 0.001
Substance usevs No substance use
aOR 1.61 (95% CI 1.53–1.70); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| MACE | 1.53 (1.46–1.61) | P < 0.001 | |
| Maternal mortality | 2.65 (2.15–3.25) | P < 0.001 | |
| CV events, by individual substanceAmphetamine/methamphetaminevs No substance useStrongest association | 2.71 (2.35–3.12) | P < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Maternal mortality
- All substances other than cocaine and cannabis significantly associated with maternal death
Cardiovascular (CV) events, by individual substance
- All individual substances had an increased association with CV events
Original publication
Substance Use in Pregnancy and its Association With Cardiovascular Events. JACC Adv. Published 14 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →