High-Density Lipoprotein Cardioprotection Function Deteriorates as Women Transition Through Menopause: The SWAN HDL Study
Authors' conclusion
In women, higher CEC is associated with a lower risk of subclinical vascular health only before menopause. Higher CEC is not a consistent indicator of greater cardiovascular disease protection in women traversing menopause.
Study context
- Population
- Women transitioning through menopause
- Participants
- 279 women
- Exposure
- Association of HDL cholesterol efflux capacity (CEC) with subclinical vascular health by time relative to final menstrual period (FMP)
- Outcome
- Composite subclinical vascular health score:
- Carotid intima-media thickness
- Carotid-femoral pulse wave velocity
- CAC score >10
- Follow-up
- By time relative to FMP
Methodological detailsBayesian hierarchical linear mixed effects model
- Bayesian hierarchical linear mixed effects model
Main finding
As reported in the abstract
Interaction CEC × time relative to FMP: pre-FMP protective association of CEC diminishes after FMP (unadjusted and adjusted models)
posterior probability >0.99
Observational data: associations, not effects.
Further findings
Racial subgroups: Black vs White women
- Protective association of CEC diminished more rapidly in Black than White women
- posterior probability >0.90
Original publication
High-Density Lipoprotein Cardioprotection Function Deteriorates as Women Transition Through Menopause: The SWAN HDL Study. JACC Adv. Published 16 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →