Heart failure & cardiomyopathies
Systematic Review and Meta-Analysis to Predict Mortality in Heart Failure with Preserved Ejection Fraction: Development and Validation of the HF-DANAS Score
Authors' conclusion
This study developed an HF-DANAS scoring system for the HFpEF mortality risk containing seven predictors, providing clinicians with a simple assessment tool that can help improve clinical management.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
- Participants
- 34,196 patients30 cohort studies
- Comparison
- Low risk vs Moderate risk vs High risk
- Outcome
- All-cause mortality (risk factors and risk prediction model)
Methodological detailsexternal validation cohort (Chinese Heart Failure Center database)
- External validation cohort (Chinese Heart Failure Center database)
Pooled result
As reported in the abstract
Predictors of all-cause mortality (meta-analysis)
Relative risk (95% CI)P value
Age > 75 years
2.07(1.83–2.35)
P < 0.001Male sex
1.36(1.17–1.59)
P < 0.001DM
1.23(1.11–1.36)
P < 0.001Anaemia
1.53(1.41–1.67)
P < 0.001Albumin < 3.2 g/dL
1.29(1.14–1.47)
P < 0.001AF
1.27(1.12–1.43)
P < 0.001NYHA class III/IV
1.63(1.43–1.87)
P < 0.001- Model AUC
- 71.3% (95% CI: 0.696-0.736)
- Optimal cut-off
- 10.75
- Sensitivity
- 0.778
- Specificity
- 0.566
Further pooled results
Deaths by risk class · 1-year follow-up
Mortality by risk class · 5 years
Original publication
Systematic Review and Meta-Analysis to Predict Mortality in Heart Failure with Preserved Ejection Fraction: Development and Validation of the HF-DANAS Score. ESC Heart Fail. Published 8 August 2024. doi:10.
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