Heart failure & cardiomyopathies
Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation: The Hózhó Randomized Clinical Trial
Primary result · Increase in number of GDMT drug classes filled from pharmacyResult — go to the resultOdds ratio 12.99 95% CI 6.87–24.53Authors' conclusion
In this heart failure trial in Navajo Nation, a telephone-based strategy of remote initiation and titration for outpatients with heart failure with reduced ejection fraction led to improved rates of guideline-directed medical therapy at 30 days compared with usual care.
Study context
- Population
- American Indian adults (≥18 years) with HFrEF receiving care at 2 Indian Health Service facilities in rural Navajo Nation
- Participants
- 103 adults
- Comparison
- Telephone-based GDMT initiation and titration with home BP telemonitoring vs usual care
- Primary endpoint
- Increase in the number of guideline-directed drug classes filled from the pharmacy
- Follow-up
- 30 days postrandomization
Methodological detailsstepped-wedge, pragmatic comparative effectiveness trial, 2 Indian Health Service facilities, Conducted February to August 2023, 5 time points (30-day intervals) until all patients crossed over into the intervention
- Stepped-wedge
- Pragmatic comparative effectiveness trial
- 2 Indian Health Service facilities
- Conducted February to August 2023
- 5 time points (30-day intervals) until all patients crossed over into the intervention
Primary result
As reported in the abstract
Increase in number of GDMT drug classes filled from pharmacy
Odds ratio
12.99
95% CI 6.87–24.53
P < 0.001
By group
Interventionvs Usual care
OR 12.99 (95% CI 6.87–24.53); P < 0.001
- NNT for telehealth intervention to increase GDMT drug classes
- 1.88
Original publication
Telephone-Based Guideline-Directed Medical Therapy Optimization in Navajo Nation: The Hózhó Randomized Clinical Trial. JAMA Intern Med. Published 1 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →