Arrhythmias & electrophysiology
Temporal Trends in Atrial Fibrillation Ablation in the Elderly: Incidence of Major Adverse Cardiovascular Events (MACE) and Recurrence Rates
Main finding · 5-year MACE, last time periodResult — go to the resultHazard ratio 1.52 95% CI 1.26–1.83Authors' conclusion
AF ablation use in the elderly has significantly increased over time. A notable decrease in MACE was evident across all age cohorts, with a particularly pronounced trend observed among the elderly population. Age was not an independent predictor of the composite endpoint.
Study context
- Population
- Individuals undergoing first-time atrial fibrillation (AF) ablation, Denmark, 2001–2020
- Exposure
- First-time AF ablation by age group (<60, 60-74, ≥75 years) across 4 consecutive 5-year intervals
- Outcome
- MACE; composite of AF-related hospitalizations, repeat AF ablation or use of AADs
- Follow-up
- 5-year MACE; 1-year composite
Methodological detailsnationwide Danish administrative registers
- Nationwide Danish administrative registers
Main finding
5-year MACE, last time period
Hazard ratio
1.52
95% CI 1.26–1.83
≥75
HR 1.52 (95% CI 1.26–1.83)
As reported in the abstract
- Elderly undergoing AF ablation increased significantly, from 0 in 2001
- 9% in 2020
- 5-year MACE incidence in elderly decreased from
- 61.9% (95% CI: 41.1%-82.7%)
- 5-year MACE incidence in elderly decreased to
- 38.1% (95% CI: 31.9%-44.2%)
Observational data: associations, not effects.
Further findings
Composite of AF-related hospitalizations, repeat AF ablation or AAD use · 1 year
- Composite outcome varied from 35.6% to 52.0%; age not a consistent predictor
Original publication
Temporal Trends in Atrial Fibrillation Ablation in the Elderly: Incidence of MACE and Recurrence Rates. JACC Clin Electrophysiol. Published 13 November 2024. doi:10.
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