Temporal Trends in Noncardiovascular Morbidity and Mortality Following Acute Myocardial Infarction
Authors' conclusion
Although cardiovascular mortality following MI improved substantially during 2000 to 2017, the risk of noncardiovascular morbidity increased. Moreover, noncardiovascular causes constitute an increasing proportion of post-MI mortality.
Study context
- Population
- All Danish patients with myocardial infarction (MI), 2000 to 2017
- Participants
- 136,293 consecutive patients
- Exposure
- 2015 to 2017 vs 2000 to 2002
- Outcome
- CV and noncardiovascular mortality, incident cancer, incident renal disease, severe infectious disease
- Follow-up
- 1 year
Main finding
As reported in the abstract
1-year risk
2000 to 2002
- CV mortality
- 18.4%
- Noncardiovascular mortality
- 5.8%
- Proportion of total mortality noncardiovascular
- 24.1%
- Incident cancer
- 1.9%
- Incident renal disease
- 1.0%
- Infectious disease
- 5.5%
2015 to 2017
- CV mortality
- 7.6%
- Noncardiovascular mortality
- 5.0%
- Proportion of total mortality noncardiovascular
- 39.5%
- Incident cancer
- 2.4%
- Incident renal disease
- 1.6%
- Infectious disease
- 9.1%
CV mortality
2000 to 200218.4%
2015 to 20177.6%
Noncardiovascular mortality
2000 to 20025.8%
2015 to 20175.0%
Proportion of total mortality noncardiovascular
2000 to 200224.1%
2015 to 201739.5%
Incident cancer
2000 to 20021.9%
2015 to 20172.4%
Incident renal disease
2000 to 20021.0%
2015 to 20171.6%
Infectious disease
2000 to 20025.5%
2015 to 20179.1%
2015 to 2017 vs 2000 to 2002Standardized relative risk (95% CI)
Cancer; standardized for patient characteristics
0.99(0.91–1.07)
Renal disease; standardized for patient characteristics
1.28(1.15–1.41)
Infectious disease; standardized for patient characteristics
1.28(1.23–1.34)
Observational data: associations, not effects.
Original publication
Temporal Trends in Noncardiovascular Morbidity and Mortality Following Acute Myocardial Infarction. J Am Coll Cardiol. Published 5 September 2023. doi:10.
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