Arrhythmias & electrophysiology
The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy
Authors' conclusion
This study showed that regional functional abnormalities measured by echocardiographic deformation imaging can further refine personalized arrhythmic risk prediction when added to the ARVC risk calculator.
Study context
- Population
- Patients with definite arrhythmogenic right ventricular cardiomyopathy (ARVC), no prior sustained ventricular arrhythmia (VA), echocardiogram suitable for deformation analysis (aged 41 ± 17 years, 50% female)
- Participants
- 150 patients
- Exposure
- Echocardiographic deformation parameters added to the ARVC risk calculator vs calculator-predicted risk alone
- Outcome
- First-time sustained ventricular arrhythmia (VA)
- Follow-up
- Median 6.3 (IQR 3.1-9.8) years
Methodological detailstwo referral centres, consecutive patients
- Two referral centres
- Consecutive patients
Main finding
As reported in the abstract
First-time sustained VA · median follow-up 6.3 years
Hazard ratio (95% CI)P value
RV free wall longitudinal strain
1.07(1.02–1.11)
P = 0.004Regional RV deformation patterns
4.45(1.07–18.57)
P = 0.040- Patients with first-time sustained VA
- 37 (25%)
- C-statistic with either RV parameter added to calculator (from 0.78)
- 0.82
- Akaike information criterion change
- > 2
Observational data: associations, not effects.
Original publication
The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 20 July 2023. doi:10.
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