Arrhythmias & electrophysiology

The Association Between Chronic Kidney Disease and Third-Degree Atrioventricular Block: A Danish Nationwide Study

JACC Clin ElectrophysiolPublished Nested case-control study

Main finding · 3AVBResult — go to the resultHazard ratio 1.83 95% CI 1.73–1.93

Authors' conclusion

CKD was independently associated with a higher rate of 3AVB, especially for patients using dialysis.

Study context

Population
Patients with third-degree AV block (3AVB) and matched controls, Denmark, July 1995–December 201831,301 cases
Comparison
Chronic kidney disease (CKD) vs no CKD
Outcome
3AVB
Methodological detailspopulation-based, risk set matched 1:5 on sex and birth year, Danish administrative registries
  • Population-based
  • Risk set matched 1:5 on sex and birth year
  • Danish administrative registries

Main finding

As reported in the abstract

Hazard ratio

1.83

95% CI 1.73–1.93

CKDvs No CKD
HR 1.83 (95% CI 1.73–1.93)

Observational data: associations, not effects.

Further findings

OutcomeEstimate
3AVB, by dialysis status (stratified)CKDvs No CKDDialysisHR 7.71 (95% CI 5.84–10.18)
3AVB, by dialysis status (stratified)CKDvs No CKDNondialysis CKDHR 1.73 (95% CI 1.64–1.83)
Pacemaker implantationCKDvs No CKDDialysisOR 0.77 (95% CI 0.60–0.98)
Pacemaker implantationCKDvs No CKDNondialysis CKDOR 1.04 (95% CI 0.96–1.12)

Original publication

The Association Between Chronic Kidney Disease and Third-Degree Atrioventricular Block: A Danish Nationwide Study. JACC Clin Electrophysiol. Published 18 December 2024. doi:10.1016/j.jacep.2024.10.007

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