The Impact of Changes in Depression on Cardiovascular Outcomes in Patients With Coronary Heart Disease
Authors' conclusion
Increasing or persistent depression predicts MACE in individuals with CHD.
Study context
- Population
- Patients with coronary heart disease (CHD) (median age 65.5 years, 31.6% female)2,639 repeated PHQ8 at 1 year
- Participants
- 3,483 patients
- Exposure
- Changes in depression over 1 year and major adverse cardiovascular events (MACE)
- Outcome
- MACE:
- CV death
- MI
Methodological detailsEmory Cardiovascular Biobank, Fine-Gray competing-risk models
- Emory Cardiovascular Biobank
- Fine-Gray competing-risk models
Main finding
As reported in the abstract
MACE
Subdistribution hazard ratio (95% CI)P value
Persistent depressionvs Never depression
2.78(1.2–6.5)
P = 0.017Δ PHQ8 (increasing depressive symptoms)
1.06(1.02–1.09)
P < 0.001- Difference in MACE incidence across groups
- P < 0.001
Observational data: associations, not effects.
Further findings
Overall MACE incidence and depression category distribution
- Overall MACE incidence and depression category distribution — MACE incidence overall
- 14%
- Overall MACE incidence and depression category distribution — MACE incidence in those with follow-up PHQ8
- 8.7%
- Overall MACE incidence and depression category distribution: per_group values are proportions of participants in each category
Original publication
The Impact of Changes in Depression on Cardiovascular Outcomes in Patients With Coronary Heart Disease. JACC Adv. Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →