Heart failure & cardiomyopathies
Trajectory of Cognitive Function After Incident Heart Failure
Authors' conclusion
In this pooled cohort study, incident HF diagnosis was associated with initial decreases in global cognition and executive function and faster, persistent declines in these domains at follow-up.
Study context
- Population
- Adults without heart failure (HF), stroke, or dementia from 6 US population-based studies from 1971 to 20191,407 (5%) received an incident diagnosis of HF
- Participants
- 29,614 adults
- Exposure
- Cognitive change with incident HF diagnosis, controlling for pre-HF cognitive trajectories and participant factors
- Incident HFn = 1,407
- Outcome
- Change in global cognition (t score points)
- Follow-up
- Median 6.6 (Q1-Q3, 5.0-19.8) years
Methodological details6 US population-based studies, linear mixed-effects models
- 6 US population-based studies
- Linear mixed-effects models
Main finding
As reported in the abstract
Initial decrease in global cognition with incident HF diagnosis
−1.1 points
95% CI −1.4 to −0.8
Rate of decline in global cognition after HF
−0.1 points per year
95% CI −0.2 to −0.1
Observational data: associations, not effects.
Secondary outcomes
Executive function (secondary outcome)
- Initial decrease with incident HF diagnosis
- −0.6 points [95% CI, −1.0 to −0.3]
- Rate of decline after HF
- −0.2 points per year [95% CI, −0.2 to −0.1]
Global cognition decrease after HF, by subgroup
- Larger decreases in global cognition after HF were seen with older age, female sex, and White race
Memory (secondary outcome)
- Initial decline
- −0.5 points (95% CI, −1.4 to +0.3)
- Slope
- −0.1 points per year (95% CI, −0.3 to 0.0)
- Not statistically significant but showed a similar trend
Original publication
Trajectory of Cognitive Function After Incident Heart Failure. Circ Heart Fail. Published 18 February 2025. doi:10.
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