Cohort study
Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation
- Registry-based cohort study
- consecutive patients
- STS/ACC TVT Registry
Authors' conclusion
In this registry-based study of patients with degenerative MR undergoing transcatheter mitral valve repair, the procedure was safe and resulted in successful repair in 88.9% of patients. The lowest mortality was observed in patients with mild or less residual MR and low mitral gradients.
Study context
- Population
- Patients with isolated moderate to severe or severe degenerative mitral regurgitation (MR) undergoing nonemergent transcatheter mitral valve repair (MitraClip), US, 2014–2022
- Participants
- 19,088 patients
- Exposure
- MR success vs Unsuccessful procedure
- Outcome
- MR success (moderate or less residual MR and mean mitral gradient <10 mm Hg)
Main finding
As reported in the abstract
MR success
MR success achieved
88.9%
Observational data: associations, not effects.
Further findings
| Outcome | MR success | Unsuccessful procedure | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Mortality · 1 year | 14.0% | 26.7% | 0.49 (0.42–0.56) | P < 0.001 | |
| HF readmission · 1 year | 8.4% | 16.9% | 0.47 (0.41–0.54) | P < 0.001 | |
| Mortality, mild or less residual MR and mean gradient ≤5 mm Hg vs unsuccessful procedure (subgroup) · 1 year · 11.4% vs 26.7% · lowest mortality among patients with MR success | 0.40 (0.34–0.47) | P < 0.001 | |||
| 0.20.5125Adjusted hazard ratio (log scale) |
Death, stroke and mitral valve reintervention · 30 days
- Death
- 2.7%
- Stroke
- 1.2%
- Mitral valve reintervention
- 0.97%
Original publication
Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation. JAMA. Published 23 May 2023. doi:10.1001/jama.2023.7089
Summarised from the published abstract; every number is checked against it