Heart failure & cardiomyopathies
Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations
Authors' conclusion
Low TSAT, but not ferritin concentrations, is significantly associated with adverse outcomes in HF. Low TSAT is more strongly associated with outcomes in HF with preserved ejection fraction. Pathways related to inflammation and lipid metabolism are associated with low TSAT in HF.
Study context
- Population
- Participants with heart failure with reduced/mid-range or preserved left ventricular ejection fraction enrolled in the PHFS (Penn heart failure (HF) Study)participants with HF · HF with reduced/mid-range ejection fraction 1,821 · HF with preserved ejection fraction 229
- Participants
- 2,050 participants
- Exposure
- Prognostic and proteomic associations of ferritin, serum iron, and transferrin saturation (TSAT)
- Outcome
- All-cause death
Main finding
As reported in the abstract
Standardized hazard ratio (95% CI)P value
TSATlow TSAT associated with risk
0.84(0.76–0.93)
P = 0.001Serum ironlow serum iron associated with risk
0.87(0.79–0.96)
P = 0.007Observational data: associations, not effects.
Further findings
Death or HF-related admission
| Standardized hazard ratio (95% CI) | P value | ||
|---|---|---|---|
| TSAT | 0.89 (0.83–0.95) | P = 0.0006 | |
| 0.512Standardized hazard ratio (log scale) |
Proteins associated with TSAT
| β | P value | |
|---|---|---|
| TFRC | −0.455 | P < 0.0001 |
| CRP | −0.355 | P < 0.0001 |
- Proteins associated with TSAT — Proteins associated with TSAT
- 359
Interaction between TSAT and HF with preserved ejection fraction status
- TSAT was more strongly associated with the risk of death and death or HF-related admission in HF with preserved ejection fraction
Iron deficiency (ID) and absolute ID by current criteria
- ID and absolute ID defined by current criteria were not associated with death or death or HF-related admission
- TSAT was associated with outcomes regardless of the presence of functional versus absolute ID
Proteins associated with TSAT
- Pathway analyses demonstrated associations with lipid metabolism, complement activation, and inflammation
Original publication
Transferrin Saturation, Serum Iron, and Ferritin in Heart Failure: Prognostic Significance and Proteomic Associations. Circ Heart Fail. Published 20 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →