Update on long-term cardiovascular risk after pre-eclampsia: a systematic review and meta-analysis
Authors' conclusion
Compared to women who experienced a normal pregnancy, those suffering from PE have about double the risk of lifetime cardiovascular disease.
Study context
- Population
- Women with a history of pre-eclampsia vs controls; randomised, cohort or case-control studies with adjusted estimates and ≥1 year follow-up22 studies
- Comparison
- History of pre-eclampsia (PE) vs normal pregnancy
- Outcome
- CV disease: CV death, CHD, HF and stroke
Methodological detailsrandom-effect model, adjusted effect sizes, PubMed, MEDLINE, Scopus and EMBASE searched from inception to May 2023, following PRISMA
- Random-effect model
- Adjusted effect sizes
- PubMed, MEDLINE, Scopus and EMBASE searched from inception to May 2023, following PRISMA
Pooled result
As reported in the abstract
- CV death; I2 56%
- Effect size (ES) 2.08 (95% CI 1.70–2.54); P < 0.00001
- Coronary artery diseases; I2 87%
- ES 2.04 (95% CI 1.76–2.38); P < 0.00001
- HF; I2 83%
- ES 2.47 (95% CI 1.89–3.22); P < 0.00001
- Stroke; I2 72%
- ES 1.75 (95% CI 1.52–2.02); P < 0.00001
Further pooled results
Risk over follow-up time
- Risk evident in first 1-to-3 years of follow-up and remains significant until 39 years
Original publication
Update on long-term cardiovascular risk after pre-eclampsia: a systematic review and meta-analysis. Eur Heart J Qual Care Clin Outcomes. Published 16 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →