Arrhythmias & electrophysiologyCohort study
Use of a taurolidine containing antimicrobial wash to reduce cardiac implantable electronic device infection
- Prospective observational study
- historical control
- single-centre
Patients with >1 procedure censored for the last treatment group and reassigned at the next procedure
Authors' conclusion
TauroPace is safe but more effective than H2O2 in reducing CIED infection.
Study context
- Population
- Patients undergoing invasive cardiac implantable electronic device (CIED) procedures, 1 January 2017 to 28 February 2022
- Exposure
- TauroPace vs 3% H2O2 antimicrobial wash
- TauroPacen = 654 procedures on 631 patients
- H2O2n = 551 procedures on 532 patientsreference
- Outcome
- Major CIED infection
- Follow-up
- Within 3 months
Main finding
As reported in the abstract
CIED infection
P = 0.0075
Observational data: associations, not effects.
Secondary outcomes
Death · till end of follow-up
P = 0.33
Baseline risk factors for infection
- More patient risk factors in TauroPace than H2O2
- P = 0.0058
- Similar device and procedure-specific risk factors
- P = 0.17
Safety
Non-infection related adverse events
P = 0.0802
Original publication
Use of a taurolidine containing antimicrobial wash to reduce cardiac implantable electronic device infection. Europace. Published 13 October 2023. doi:10.1093/europace/euad306
Summarised from the published abstract; every number is checked against it