Arrhythmias & electrophysiology
Validation of novel risk prediction models in patients with Brugada syndrome: A multicenter study in Japan
Authors' conclusion
This Japanese multicenter registry demonstrated that the novel risk stratification model could not accurately predict future VF events in patients with BrS but without prior VF.
Study context
- Population
- Patients with Brugada syndrome in a Japanese multicentre cohort (314 without prior ventricular fibrillation (VF))314 without prior VF
- Participants
- 413 patients
- Exposure
- PAT score ≥ 10 vs < 10
- PAT ≥ 10n = 173
- PAT < 10n = 240reference
- Outcome
- Incidence of VF events during follow-up
- Follow-up
- 106.8-month follow-up
Methodological detailsmulticentre, 59 hospitals in Japan, validation study
- Multicentre
- 59 hospitals in Japan
- Validation study
Main finding
As reported in the abstract
VF events, total cohort
P < 0.0001
- VF events overall
- 54 patients (13.1%)
Observational data: associations, not effects.
Further findings
VF events, patients without prior VF (n = 314) · 106.8-month follow-up · no difference
P = 0.22
| Outcome | PAT ≥ 10 | PAT < 10 |
|---|---|---|
| Prediction of future VF by PAT score ≥ 10 | ||
| Sensitivity | 42.9% | — not stated in the abstract |
| Specificity | 73.3% | — not stated in the abstract |
— not stated in the abstract
- VF events, patients without prior VF (n = 314) — VF events without prior VF
- 14 (4.5%)
Original publication
Validation of novel risk prediction models in patients with Brugada syndrome: A multicenter study in Japan. Heart Rhythm. Published 15 September 2024. doi:10.
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