Arrhythmias & electrophysiology
Validation of the Prevention of Arrhythmia Device Infection Trial (PADIT) (prevention of arrhythmia device infection trial) risk score for infection and infection subtypes
Authors' conclusion
The PADIT score was independently validated with discrimination and calibration similar to the original derivation cohort. Importantly, prior procedures predicted pocket but not systemic infection. Overall, PADIT performed well in predicting both subtypes, with the strongest model fit observed for systemic infection.
Study context
- Population
- Cardiac Implantable Electronic Device (CIED) procedures at the University of Ottawa Heart Institute, 2007–2020
- Participants
- 14,225 procedures
- Outcome
- PADIT score discrimination (C-statistic) and calibration for CIED infection and infection subtypes (pocket, systemic)
Methodological detailsprospective registry, single-centre, blinded independent adjudication
- Prospective registry
- Single-centre
- Blinded independent adjudication
Performance
As reported in the abstract
CIED infection (validation of PADIT score)
| Test or model | C-statistic, any infection | C-statistic, pocket infection | C-statistic, systemic infection | C-statistic, derivation cohort |
|---|---|---|---|---|
| PADIT score | 0.687 (95% CI 0.655-0.743) | 0.691 (95% CI 0.649-0.761) | 0.746 (95% CI 0.707-0.848) | 0.702, 95% CI 0.661-0.741 |
PADIT score
C-statistic, any infection0.687 (95% CI 0.655-0.743)
C-statistic, pocket infection0.691 (95% CI 0.649-0.761)
C-statistic, systemic infection0.746 (95% CI 0.707-0.848)
C-statistic, derivation cohort0.702, 95% CI 0.661-0.741
- Infections adjudicated
- 103 infections (0.73%)
- Pocket infections
- 71 (69%)
- Systemic infections
- 32 (31%)
Further findings
Number of prior procedures as risk factor, by subtype
- Strongly associated with pocket but not systemic infection
Original publication
Validation of the PADIT (prevention of arrhythmia device infection trial) risk score for infection and infection subtypes. Europace. Published 29 January 2026. doi:10.
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