Arrhythmias & electrophysiology
Variations in threshold values for border zone and dense scar produce significant changes in scar parameters obtained by ADAS-3D
Authors' conclusion
Variations in threshold values result in statistically significant and high-magnitude changes in the quantification of scar parameters by ADAS-3D.
Study context
- Population
- Consecutive patients with previous MI who underwent cardiac magnetic resonance (CMR)
- Participants
- 87 patients
- Exposure
- 9 threshold combinations for dense scar (55%/60%/65%) and border zone (BZ) (35%/40%/45%) of maximum pixel signal intensity in ADAS-3D
- Outcome
- Degree of change in ADAS-3D scar measurements with different dense scar and BZ thresholds
Methodological detailssingle-centre, observational, consecutive patients
- Single-centre
- Observational
- Consecutive patients
Main finding
As reported in the abstract
- Highly significant differences in all scar parameters across thresholds
- P < .001
- Percentage difference in BZ channel numbers and channel mass in all 36 comparisons
- up to 200%
- Absolute difference in number of channels
- up to 10 channels
- Highest median channel mass (thresholds 35-65) vs lowest (45-55 cutoffs)
- 59-fold higher
Observational data: associations, not effects.
Original publication
Variations in threshold values for border zone and dense scar produce significant changes in scar parameters obtained by ADAS-3D. Heart Rhythm. Published 2 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →