Coronary disease & ACSCohort study
Vascular Remodeling in Coronary Microvascular Dysfunction
- Prospective cohort study
Authors' conclusion
Patients with CMD and high minimal microvascular resistance have smaller epicardial vessels than those without CMD. Coronary CTA detected high minimal microvascular resistance with very good diagnostic capacity.
Study context
- Population
- Patients with ANOCA undergoing continuous thermodilution assessment and coronary computed tomography angiography (CTA)
- Participants
- 153 patients
- Exposure
- Coronary microvascular dysfunction (CMD) and high microvascular resistance vs Controls
- CMDn = 68
- CMD and high microvascular resistancen = 22
- Outcome
- Minimal microvascular resistance and associated vascular remodeling (lumen volume by coronary CTA)
Main finding
As reported in the abstract
Lumen volume vs minimal microvascular resistance
P < 0.001
- Correlation of lumen volume with minimal microvascular resistance (r)
- −0.59 [95% CI: −0.45 to −0.71]; P < 0.001
- Lumen volume independently associated with minimal microvascular resistance
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | CMD | CMD and high microvascular resistance | Controls | P value |
|---|---|---|---|---|
| Coronary flow reserve | 1.9 ± 0.38 | Not reported in the abstract | 3.2 ± 0.81 | P < 0.001 |
Lumen volume by coronary CTA for detecting high microvascular resistance
- AUC
- 0.79 (95% CI: 0.69-0.88)
Original publication
Vascular Remodeling in Coronary Microvascular Dysfunction. JACC Cardiovasc Imaging. Published 11 September 2024. doi:10.1016/j.jcmg.2024.07.018
Summarised from the published abstract; every number is checked against it