Valvular & structural heart disease
Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves
Authors' conclusion
Significant associations were discovered between 4D flow CMR derived whole-cardiac cycle WSS and circulating biomarkers representing inflammation and collagen synthesis, suggesting an intricate interplay between haemodynamics and the processes of inflammation and collagen synthesis in patients with early aortic dilation and tricuspid aortic valves.
Study context
- Population
- Patients with mild-to-moderate ascending aortic dilation and tricuspid aortic valves
- Participants
- 47 vs 50
- Comparison
- Ascending aortic dilation vs no dilation
- Casesn = 47
- Controlsn = 50reference
- Outcome
- Associations between ascending aortic haemodynamics (flow displacement, WSS, oscillatory shear index) by 4D flow CMR and circulating biomarkers (interleukin-6, collagen type I α1 chain, MMPs, inhibitors of MMPs)
Methodological detailssex- and age-matched controls
- Sex- and age-matched controls
Main finding
As reported in the abstract
Maximum time-averaged wall shear stress (WSS) vs interleukin-6, r
0.539
P < 0.001
Maximum oscillatory shear index vs collagen type I α1 chain in cases, r
−0.575
P < 0.001
Observational data: associations, not effects.
Further findings
Haemodynamics, cases vs controls
- Cases had lower peak systolic WSS, higher flow displacement and higher mean oscillatory shear index than controls
Biomarkers, cases vs controls
- No significant differences in biomarkers between the groups
Original publication
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