Heart failure & cardiomyopathies

A body shape index for visceral fat and its changes predict cardiovascular outcomes of heart failure with preserved ejection fraction

Eur Heart J Qual Care Clin OutcomesPublished Secondary analysis of the TOPCAT randomised trial

Authors' conclusion

ABSI was independently associated with long-term prognosis in patients with HFpEF, and a history of high ABSI was associated with a poorer prognosis later in life

Study context

Population
Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trialmean follow-up 3.9 years
Participants
3,319 patients
Comparison
A body shape index (ABSI) tertiles

Primary result

As reported in the abstract

CV outcomes by ABSI tertile (multivariate-adjusted) · mean follow-up 3.9 years
ABSI >0.084 vs ABSI ≤0.078Hazard ratio (95% CI)
All-cause mortality
1.464(1.150–1.864)
CV death
1.685(1.241–2.289)
MI
1.778(1.088–2.904)
MACE
1.430(1.123–1.822)

Further findings

Previous or current high ABSI

HR (95% CI)
Previous or current high ABSIAll-cause mortality1.635 (1.116–2.396)
Previous or current high ABSICV death1.724 (1.071–2.775)
Previous or current high ABSIMI2.021 (0.878–4.653)
Previous or current high ABSIMACE1.653 (1.117–2.447)

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

A body shape index for visceral fat and its changes predict cardiovascular outcomes of heart failure with preserved ejection fraction. Eur Heart J Qual Care Clin Outcomes. Published 28 February 2025. doi:10.1093/ehjqcco/qcaf005

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