Arrhythmias & electrophysiology
A computed tomography–based evaluation and comparison of ganglionated plexus targeting techniques for cardioneuroablation
Authors' conclusion
CT-based fat pad segmentation reveals significant interpatient variability in GP anatomy. GPs show low colocalization with signal fragmentation, causing inaccurate localization based on fragmentation alone. An anatomy-focused approach offers a more targeted ablation strategy.
Study context
- Population
- Patients undergoing cardioneuroablation (CNA) or AF ablation
- Participants
- 26 patients
- Comparison
- Ganglionated plexus (GP) targeting approaches
- Outcome
- Correlation between epicardial fat pads and signal fragmentation
Methodological detailsGPs identified by computed tomography (CT)-based fat segmentation; CT-derived atrial meshes merged with electroanatomic mapping meshes
- GPs identified by CT-based fat segmentation; CT-derived atrial meshes merged with electroanatomic mapping meshes
Main finding
As reported in the abstract
Left atrium, ρ
0.01 ± 0.13
P = .73
Left atrium, ϕ
−0.00 ± 0.10
P = .94
Right atrium, ρ
0.11 ± 0.09
P < .001
Right atrium, ϕ
−0.10 ± 0.08
P < .001
Further findings
- Left atrium: anatomic vs FEGM
- 3.74% vs 17.0% (P < .001)
- Right atrium: anatomic vs FEGM
- 3.45% vs 9.53% (P < .001)
- FEGM approach associated with a more extensive ablation area
Original publication
A computed tomography–based evaluation and comparison of ganglionated plexus targeting techniques for cardioneuroablation. Heart Rhythm. Published 16 January 2025. doi:10.
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