Heart failure & cardiomyopathies
A Pilot Study of S100A4, S100A8/A9, and S100A12 in Dilated Cardiomyopathy: Novel Biomarkers for Diagnosis or Prognosis?
Authors' conclusion
S100A4, S100A8/A9, and S100A12 may be additional diagnostic tools for human DCM recognition, and the combination of these three indicators helped to improve the accuracy of a single index to diagnose DCM. Additionally, S100A4 was identified as a significant predictor of prognosis in patients with DCM.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM) and controls, Zhongshan Hospital, January 2017–January 2019238 DCM, 65 controls
- Comparison
- S100A4, S100A8/A9 and S100A12 for diagnosis and prognosis of DCM
- Outcome
- Diagnosis of DCM (ROC)
Methodological detailspilot study, single-centre, consecutive enrolment, screening and validation sets
- Pilot study
- Single-centre
- Consecutive enrolment
- Screening and validation sets
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| Combination | 0.88 (95% CI 0.84-0.93) |
| S100A4 | 0.74 (95% CI 0.68-0.81) |
| S100A8/A9 | 0.82 (95% CI 0.77-0.88) |
| S100A12 | 0.80 (95% CI 0.72-0.88) |
AUC
Combination0.88 (95% CI 0.84-0.93)
S100A40.74 (95% CI 0.68-0.81)
S100A8/A90.82 (95% CI 0.77-0.88)
S100A120.80 (95% CI 0.72-0.88)
- Combination better than any single marker
- P < 0.01
- S100A4, S100A8/A9 and S100A12 significantly increased in DCM
- P < 0.001
Further findings
| Outcome | S100A4 ≥75th percentile | S100A4 <75th percentile | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACE (cardiac death or HF rehospitalization) by S100A4 level · median follow-up 33.5 monthsCox regression; independent predictor | 61.40% | 42.37% | 1.65 (1.11–2.45) | P < 0.05 | |
| 0.512Hazard ratio (log scale) |
- MACE (cardiac death or HF rehospitalization) by S100A4 level — MACE overall
- 110 patients (47.01%)
- MACE (cardiac death or HF rehospitalization) by S100A4 level — No significant difference in MACE by S100A8/A9 or S100A12; not independent predictors
- P > 0.05
Correlations: positive with Lg (NT-proBNP), IL-1β, TGF-β, CRP, LV end-diastolic and end-systolic diameter; negative with LVEF
- Significant correlations for all three proteins
- P < 0.05
Original publication
A Pilot Study of S100A4, S100A8/A9, and S100A12 in Dilated Cardiomyopathy: Novel Biomarkers for Diagnosis or Prognosis? ESC Heart Fail. Published 11 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →