Heart failure & cardiomyopathies
Association between cardiac cachexia and adverse outcomes in patients with heart failure: a meta-analysis of cohort studies
Pooled result · All-cause mortalityResult — go to the resultHazard ratio 1.59 95% CI 1.34–1.89Authors' conclusion
Cardiac cachexia is associated with a higher risk of all-cause mortality and MACEs in patients with heart failure. Assessing cardiac cachexia may provide valuable prognostic information for these patients.
Study context
- Population
- Patients with heart failure
- Participants
- 3,821 patients9 studies
- Comparison
- Prognostic value of cardiac cachexia in patients with heart failure
- Outcome
- All-cause mortality
Methodological detailsfixed-effects model
- Fixed-effects model
Pooled result
As reported in the abstract
Hazard ratio
1.59
95% CI 1.34–1.89
Cardiac cachexia
HR 1.59 (95% CI 1.34–1.89)
Further pooled results
MACEs
| HR (95% CI) | ||
|---|---|---|
| Cardiac cachexiaIncreased risk with cardiac cachexia · fixed-effects model · adjusted HR | 2.41 (1.50–3.85) | |
| 0.20.5125Hazard ratio (log scale) |
Prevalence of cardiac cachexia
- Prevalence varied depending on definitions
- 11.2% to 37.8%
All-cause mortality, subgroup analyses
- Cardiac cachexia significantly predicted all-cause mortality regardless of study design, heart failure subtypes, sample sizes, country, patients' age, definitions of cachexia, length of follow-up, baseline body mass index, left ventricular ejection fraction, and adjustment for renal function, smoking status, New York Heart Association class or heart failure medications
Original publication
Association between cardiac cachexia and adverse outcomes in patients with heart failure: a meta-analysis of cohort studies. Heart. Published 15 March 2025. doi:10.
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