Heart failure & cardiomyopathies
Association Between Serum Sodium Level Trajectories and Survival in Patients with Heart Failure
Authors' conclusion
Serum sodium level trajectories were associated with mortality in patients with HF.
Study context
- Population
- Intensive care unit (ICU) patients with heart failure (HF) (MIMIC-III, 2001–2012), excluding deaths within 48 h of ICU admission4,760 extracted
- Participants
- 3,628 patients
- Exposure
- Serum sodium trajectories over first 48 h vs normal-steady-state trajectory
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailsMIMIC-III database, group-based trajectory modelling
- MIMIC-III database
- Group-based trajectory modelling
Main finding
As reported in the abstract
1-year mortality
Each group vs normal-steady-stateHazard ratio (95% CI)P value
Hyponatremia-slow rise
1.35(1.01–1.80)
P = 0.040Hyponatremia-rapid rise to normal
1.37(1.11–1.71)
P = 0.004Hypernatremia-rapid decline to normal
1.46(1.08–1.97)
P = 0.014Hypernatremia-slow decline
1.49(1.07–2.07)
P = 0.018Hyponatremia-rapid rise to normalfully adjusted
1.26(1.01–1.57)
P = 0.038Hypernatremia-rapid decline to normalfully adjusted
1.36(1.01–1.84)
P = 0.047Observational data: associations, not effects.
Further findings
Baseline sodium category
Original publication
Association Between Serum Sodium Level Trajectories and Survival in Patients with Heart Failure. ESC Heart Fail. Published 3 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →