Arrhythmias & electrophysiology
Atrial Standstill in the Pediatric Population: A Multi-Institution Collaboration
Authors' conclusion
AS may be associated with loss-of-function SCN5A variants. Patients demonstrate atrial and ventricular arrhythmias, and may present challenges during device placement. Patients without the capacity for atrial pacing are at risk for thromboembolic events and warrant anticoagulation.
Study context
- Population
- Patients <18 years at diagnosis of atrial standstill (absence of atrial activity), acquired disorders excluded
- Participants
- 20 patients
- Outcome
- Clinical characteristics, arrhythmias, thromboembolic events and genetics of paediatric atrial standstill
- Follow-up
- Median 6.9 years (IQR: 1.2-13.3 years)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Median age at diagnosis
- 6.6 years (IQR: 2.9-10.8 years)
- Atrial/supraventricular arrhythmias
- 16 (80%)
- VT
- 8 (40%)
- Cardiac arrests (among VT)
- 4
- Type 1 Brugada pattern
- 4
- Pacemakers implanted
- 18 (90%)
- Atrial leads attempted; pacing achieved at implantation
- 15; 4
- Thromboembolic events
- 7 (35%)
- Thromboembolic events: with atrial pacing; not on anticoagulation; on aspirin
- 0; 6; 1
- SCN5A variants
- 13 (65%)
Observational data: associations, not effects.
Original publication
Atrial Standstill in the Pediatric Population: A Multi-Institution Collaboration. JACC Clin Electrophysiol. Published 26 October 2022. doi:10.
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