Cardiovascular Outcomes in Fontan Patients With Right vs Left Univentricular Morphology: A Multicenter Study
Main findingResult — go to the resultHazard ratio 2.17 95% CI 1.45–3.45Authors' conclusion
Fontan patients with uRV vs uLV morphology have a higher incidence of adverse cardiovascular events, including atrial arrhythmia, cardiac transplantation, and all-cause mortality.
Study context
- Population
- Patients with total cavopulmonary connection Fontan palliation
- Participants
- 384 patients
- Exposure
- uRV vs uLV
- uRVn = 171
- uLVn = 213reference
- Outcome
- Composite of:
- Atrial arrhythmias
- Thromboembolic events
- Cardiac transplantation
- Death
- Follow-up
- 10.5 ± 5.9 years
Methodological detailsmulticentre, 12 centres in North America, blinded adjudicating committee, competing-risks time-to-event analyses
- Multicentre
- 12 centres in North America
- Blinded adjudicating committee
- Competing-risks time-to-event analyses
Main finding
As reported in the abstract
Hazard ratio
2.17
95% CI 1.45–3.45
P < 0.001
By group
uRV vs uLV
HR 2.17 (95% CI 1.45–3.45); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Cardiac transplantation or death | 9.09 (2.17–38.46) | P < 0.001 | |
| Atrial arrhythmias | 2.17 (1.20–4.00) | P = 0.010 | |
| Thromboembolic events | 1.64 (0.86–3.16) | P = 0.131 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Cardiovascular Outcomes in Fontan Patients With Right vs Left Univentricular Morphology: A Multicenter Study. JACC Adv. Published 20 February 2024. doi:10.
Summarised from the published abstract; every number is checked against it