Arrhythmias & electrophysiology
Clinical Characteristics and Outcomes in Patients With Atrial Fibrillation and Pathogenic TTN Variants
Authors' conclusion
TTN(+) AF patients undergo more cardioversions and have more persistent forms of AF. Approximately 50% develop LV systolic dysfunction and/or malignant ventricular arrhythmias.
Study context
- Population
- Patients presenting initially with atrial fibrillation (AF), enrolled in an AF registry with research sequencing for cardiomyopathy and arrhythmia genes57 cases matched 1:2
- Participants
- 2,794 patients
- Exposure
- TTN AF vs genotype-negative AF
- TTN(+) AFn = 57
- Controln = 114reference
- Outcome
- Characteristics and outcomes, TTN(+) AF vs genotype-negative matched controls
- Follow-up
- Median 8.3 years (Q1, Q3: 4.5, 13.7 years)
Methodological detailsAF registry, retrospective chart review
- AF registry
- Retrospective chart review
Main finding
As reported in the abstract
median 8.3 years follow-up (Q1, Q3: 4.5, 13.7 years)
| Group | Sustained VT/VF | Left ventricular (LV) systolic dysfunction (LVEF <50%) | Combined sustained VT/VF or LV systolic dysfunction |
|---|---|---|---|
| TTN(+) AF | 11% | 44% | 47% |
TTN(+) AF
Sustained VT/VF11%
Left ventricular (LV) systolic dysfunction (LVEF <50%)44%
Combined sustained VT/VF or LV systolic dysfunction47%
- TTN(+) AF vs Control subjects: P < 0.01 — low QRS voltage: 18% vs 5%
- TTN(+) AF vs Control subjects: P = 0.028 — persistent AF at enrolment: 44% vs 30%
- TTN(+) AF vs Control subjects: P < 0.01 — multiple cardioversions: 61% vs. 37%
Observational data: associations, not effects.
Further findings
- Outcomes in TTN(+) AF: sustained VT/VF, LV systolic dysfunction (LVEF <50%), combined endpoint · median 8.3 years (Q1, Q3: 4.5, 13.7 years)
- 11% · Sustained VT/VF · LV systolic dysfunction 44% · Combined VT/VF or LV systolic dysfunction 47%
Original publication
Clinical Characteristics and Outcomes in Patients With Atrial Fibrillation and Pathogenic TTN Variants. JACC Clin Electrophysiol. Published 23 October 2024. doi:10.
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