Acute cardiac care & resuscitation
Clinical Profile, Short and Long-Term Outcomes of Non-Ischaemic Cardiogenic Shock: A FRENSHOCK Sub-Analysis
Authors' conclusion
In this large study, NICS accounted for almost two-thirds of all CS cases, with substantial rates of short- and long-term mortality. Future studies should evaluate interventions to improve early stratification and management. NCT02703038.
Study context
- Population
- Patients with non-ischaemic cardiogenic shock (NICS) in the FRENSHOCK registryNICS patients (63.7%) of 772 cardiogenic shock (CS) patients included
- Participants
- 492 patients
- Outcome
- One-year mortality
- Follow-up
- 1 year
Methodological details49 centers, sub-analysis
- 49 centers
- Sub-analysis
Main finding
As reported in the abstract
One-year mortality rate was
45.7% in the overall FRENSHOCK cohort
events
- Independent factor: age (per year), aHR
- 1.03 [1.01-1.05], P < 0.01
- Independent factor: chronic kidney disease (CKD), aHR
- 1.87 [1.25-2.80], P < 0.01
- Independent factor: norepinephrine use, aHR
- 1.52 [1.02-2.26], P = 0.04
- Independent factor: active cancer, aHR
- 1.91 [1.07-3.42], P = 0.03
- Independent factor: acute renal replacement therapy, aHR
- 1.57 [1.01-2.46], P = 0.049
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Values |
|---|---|
| One-month mortalitySecondary outcome | NICS 25.6% |
| Composite of 1-year mortality, HTx, or VADSecondary outcome | NICS 53.9% |
One-month mortality
- Age, CKD and norepinephrine predictive; also associated with septic triggers
Composite of 1-year mortality, HTx, or ventricular assistance device (VAD)
- Age, CKD and norepinephrine predictive; also associated with acute mechanical circulatory support, NYHA stage ≥ 3 and fluid administration
Original publication
Clinical Profile, Short and Long-Term Outcomes of Non-Ischaemic Cardiogenic Shock: A FRENSHOCK Sub-Analysis. ESC Heart Fail. Published 25 March 2025. doi:10.
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