Coarctation of Aorta With Tricuspid Aortic Valve Is Not Associated With Ascending Aortic Aneurysm
Authors' conclusion
These findings suggest that BAV (and not COA) was associated with ascending thoracic aorta dimensions, and that patients with COA+TAV were not at a greater risk of developing ascending aortic aneurysms as compared with patients without SHD.
Study context
- Population
- Patients with coarctation of aorta, matched to patients with isolated bicuspid aortic valve (BAV) and without structural heart diseaseCoarctation of aorta (COA) 867 matched 1:1:1
- Participants
- 304 / 563 / 867 / 867
- Exposure
- COA vs isolated BAV vs no structural heart disease
- COA+BAVn = 304
- COA+tricuspid aortic valve (TAV)n = 563
- BAVn = 867
- no-SHDn = 867reference
- Outcome
- Aortic dimensions (aortic root and mid ascending aorta diameter)
- Follow-up
- Baseline and 3, 5 and 7 years
Main finding
As reported in the abstract
Aortic diameters vs no-SHD
| Group | Aortic root diameter | Mid ascending aorta diameter |
|---|---|---|
| COA+BAV | 37 mm [Q1-Q3: 30-43 mm] | 34 mm [Q1-Q3: 29-40 mm] |
| BAV | 37 mm [Q1-Q3: 30-42 mm] | 35 mm [Q1-Q3: 30-40 mm] |
| no-SHD | 32 mm [Q1-Q3: 27-35 mm] | 28 mm [Q1-Q3: 24-31 mm] |
Aortic root diameter
COA+BAV37 mm [Q1-Q3: 30-43 mm]
BAV37 mm [Q1-Q3: 30-42 mm]
no-SHD32 mm [Q1-Q3: 27-35 mm]
Mid ascending aorta diameter
COA+BAV34 mm [Q1-Q3: 29-40 mm]
BAV35 mm [Q1-Q3: 30-40 mm]
no-SHD28 mm [Q1-Q3: 24-31 mm]
- COA+BAV vs no-SHD: P < 0.001 — aortic root diameter
- COA+BAV vs no-SHD: P = 0.008 — mid ascending aorta diameter
- BAV vs no-SHD: P < 0.001 — aortic root diameter
- BAV vs no-SHD: P < 0.001 — mid ascending aorta diameter
Observational data: associations, not effects.
Safety
Acute aortic complications
- Low risk in all groups
Original publication
Coarctation of Aorta With Tricuspid Aortic Valve Is Not Associated With Ascending Aortic Aneurysm. J Am Coll Cardiol. Published 26 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it