Heart failure & cardiomyopathies
Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy
Authors' conclusion
Measures of LA structure and function offer important prognostic information in patients with DCM and enhance the prediction of adverse outcomes. LA strain was not incremental to volumetric analysis for risk prediction.
Study context
- Population
- Patients with non-ischaemic dilated cardiomyopathy (DCM) in sinus rhythm; median age 54 years, 61% men, median LVEF 42%
- Participants
- 580 patients
- Exposure
- Cardiovascular magnetic resonance (CMR) measures of left atrial (LA) structure and function for prognosis
- Outcome
- CV death or non-fatal HF events
- Follow-up
- Median 7.4 years
Main finding
As reported in the abstract
- Patients meeting primary endpoint
- 103 (18%)
- LAVImin gave greatest improvement in discrimination: C-statistic
- 0.702-0.738
- LAVImin added to baseline model: χ2 likelihood ratio
- P < 0.0001
- LAVImin categorical net reclassification index
- 0.210 (95% CI 0.023-0.392)
Observational data: associations, not effects.
Further findings
Event rates, highest tercile of LAVImin
- Similar event rates to patients with persistent AF
LA strain incremental to LA volumetric measures
- LA strain did not enhance model discrimination above LA volumetric measures
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 16 March 2024. doi:10.
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