Heart failure & cardiomyopathies
Distinct Inflammatory Milieu in Patients With Right Heart Failure
Authors' conclusion
RHF is associated with a distinct circulating inflammatory profile. Soluble CD163 and CXCL12 are novel biomarkers that can prognosticate patient outcomes.
Study context
- Population
- Patients undergoing right heart catheterization (blood from inferior vena cava and hepatic veins)
- Comparison
- Right heart failure (RHF) vs HF without RHF vs controls
- Outcome
- Circulating inflammatory markers (multiplex protein assay)
Methodological detailsindependent validation cohort
- Independent validation cohort
Main finding
As reported in the abstract
- RHF associated with elevated levels of a subset of cytokines/chemokines/growth factors vs controls
- Soluble CD163 and CXCL12 higher in RHF
- Soluble CD163 and CXCL12 predicted LV assist device/transplant-free survival in an independent validation cohort
Further findings
Hepatic expression (single-cell RNA sequencing, immunohistochemistry of human liver biopsies)
- Soluble CD163 and CXCL12 expressed by Kupffer cells; may be liver derived
Original publication
Distinct Inflammatory Milieu in Patients With Right Heart Failure. Circ Heart Fail. Published 3 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →