Efficacy of Coronary Sinus Aspiration in Reducing Contrast-Induced Nephropathy in High-Risk Patients
Authors' conclusion
While CSA was associated with lower rates of CIN in high-risk patients undergoing coronary angioplasty, procedural complications can occur.
Study context
- Population
- High-risk patients (diabetes and CKD 3) undergoing coronary angioplasty66 analysed
- Participants
- 70 patients
- Comparison
- Coronary angioplasty with coronary sinus aspiration (CSA) vs coronary angioplasty alone
- Interventionn = 33
- Controln = 33reference
- Primary endpoint
- Contrast-induced nephropathy (CIN) (serum creatinine increase ≥25% or 0.5 mg/dL)
- Follow-up
- Within 3 days following the procedure
Methodological detailssingle-centre, prospective, single-blind
- Single-centre
- Prospective
- Single-blind
Primary result
As reported in the abstract
CIN
P = 0.027
Further findings
Postprocedural serum creatinine and eGFR
- No differences
Contrast volume
- Mean injected contrast volume
- 65.2 ± 23 mL
- Estimated aspirated contrast volume
- 18.7 ± 7.1 mL
Safety
Exclusions from CSA (cannulation difficulty, procedural complication)
- Difficulties in coronary sinus cannulation
- 3
- Procedural complication
- 1
- Of 37 allocated to CSA
Original publication
Efficacy of Coronary Sinus Aspiration in Reducing Contrast-Induced Nephropathy in High-Risk Patients. JACC Adv. Published 10 September 2025. doi:10.
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