Arrhythmias & electrophysiology
Epicardial substrate ablation in patients with symptomatic Brugada syndrome: An updated systematic review and single-arm meta-analysis
Authors' conclusion
Epicardial substrate ablation shows promise for patients with BrS experiencing BrS-triggered ventricular arrhythmias, offering therapeutic efficacy with an acceptable safety profile.
Study context
- Population
- Patients with symptomatic Brugada syndrome undergoing epicardial substrate ablation
- Participants
- 555 patients13 cohort studies
- Outcome
- Resolution of type 1 Brugada electrocardiographic (ECG) pattern; elimination of abnormal electrograms (pooled proportions)
Methodological detailsrandom-effects proportional meta-analysis, PRISMA
- Random-effects proportional meta-analysis
- PRISMA
Pooled result
As reported in the abstract
Resolution of type 1 pattern
91%
95% CI 80–98%; I2 = 86%
Elimination of abnormal electrograms
91%
95% CI 78–99%; I2 = 74%
Original publication
Epicardial substrate ablation in patients with symptomatic Brugada syndrome: An updated systematic review and single-arm meta-analysis. Heart Rhythm. Published 10 January 2025. doi:10.
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