Arrhythmias & electrophysiology
Even mild mitral regurgitation is associated with incident atrial fibrillation in the general population
Main finding · Incident AF per 5% increase in MR/LA ratioResult — go to the resultHazard ratio 1.06 CI 1.00–1.13Authors' conclusion
MR, including even trace regurgitations quantified by MR/LA ratio, is independently associated with incident AF in individuals ≤ 73 years of age.
Study context
- Population
- General population (5th Copenhagen City Heart Study) undergoing transthoracic echocardiographyMitral regurgitation (MR) quantified in 4042
- Participants
- 4,466 participants
- Exposure
- MR/left atrial (LA) ratio and incident atrial fibrillation (AF)
- Outcome
- Incident AF
- Follow-up
- Median 5.3 years (IQR 4.4-6.1 years)
Methodological detailsgeneral population
- General population
Main finding
Incident AF per 5% increase in MR/LA ratio
Hazard ratio
1.06
CI 1.00–1.13
P = 0.042
MR/LA ratio, per 5% increase
HR 1.06 (CI 1.00–1.13); P = 0.042
Per 5% increase, as printed
As reported in the abstract
- Incident AF
- 198 (4.9%)
- MR present
- 1938 participants (48%)
- Trace/mild MR (MR/LA ratio ≤ 20% and ≤4 cm²)
- 1593 (39%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Incident AF per 5% increase in MR/LA ratio, participants ≤ 73 years (subgroup)Adjusted for CHARGE-AF score | 1.14 (1.06–1.24) | P = 0.001 | |
| Incident AF per 5% increase in MR/LA ratio, participants ≤ 73 years without moderate or severe MR and with normal LA size (subgroup) | 1.35 (1.09–1.68) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Original publication
Even mild mitral regurgitation is associated with incident atrial fibrillation in the general population. Eur Heart J Cardiovasc Imaging. Published 11 December 2023. doi:10.
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