Valvular & structural heart disease
Exercise-Induced Tricuspid Regurgitation: Clinical Predictors and Hemodynamic Implications
Authors' conclusion
ExTR+ is frequent, identifies heart failure with preserved ejection fraction-like phenotypes with a maladaptive exercise response, and adds information beyond resting TR.
Study context
- Population
- Consecutive patients undergoing exercise cardiac catheterization and three-dimensional echocardiography
- Participants
- 132 patients
- Outcome
- Exercise-induced TR (exTR+; ≥1 grade increase in TR severity)
Main finding
As reported in the abstract
ExTR+ occurred
34%
Further findings
Characteristics of patients with exTR+
- Older, more atrial fibrillation, higher natriuretic peptides/HFpEF probability scores, higher filling pressures, lower cardiac output
- P < 0.05
Exercise response with exTR+
- Greater right ventricular dilation, right atrial pressure rise, lower cardiac output, lower oxygen consumption
- P < 0.05
Association of tricuspid regurgitation (TR) regurgitant volume with cardiac output and oxygen consumption
- Exercise rather than resting TR regurgitant volume was more associated with cardiac output and oxygen consumption
Predictors of exTR+
- Baseline TR, OR
- 1.065
- Atrial fibrillation, OR
- 4.97
- N-terminal pro-brain natriuretic peptide, OR per pg/mL
- 1.0004
- Area under the curve
- 0.91
- P < 0.05
Original publication
Exercise-Induced Tricuspid Regurgitation: Clinical Predictors and Hemodynamic Implications. JACC Adv. Published 6 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →