Arrhythmias & electrophysiology
Genetics in Probands With Idiopathic Ventricular Fibrillation: A Multicenter Study
Authors' conclusion
In probands with IVF, undergoing genetic analysis with a broad panel, the diagnostic yield for P+ is 6.7%. P+ or VUS carrier status is a predictor of VA occurrence.
Study context
- Population
- Probands with idiopathic VF undergoing broad gene panel analysisvariant in 12
- Participants
- 45 probands
- Exposure
- P+ or variants of unknown significance (VUS) carriers vs no variants
- VUSn = 9
- P+n = 3
- Outcome
- Occurrence of ventricular arrhythmias (VA)
- Follow-up
- Mean 105.0 months
Methodological detailsmulticentre, consecutive probands
- Multicentre
- Consecutive probands
Main finding
As reported in the abstract
VA-free survival
VUS vs no variants (NO-V): P < 0.001 · P+ vs NO-V: P = 0.013
- Ventricular arrhythmias (VA) in whole cohort
- 16 patients (35.6%)
Observational data: associations, not effects.
Further findings
Diagnostic yield for P+
- Diagnostic yield for P+
- 6.7%
Deaths · mean follow-up 105.0 months
- Deaths
- 0
Original publication
Genetics in Probands With Idiopathic Ventricular Fibrillation: A Multicenter Study. JACC Clin Electrophysiol. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →