Arrhythmias & electrophysiology
Impact of Device Compression on Peridevice Leak After Left Atrial Appendage Closure: The Impression Left Atrial Appendage Closure (LAAC) Study
Authors' conclusion
In this dual-center cohort of TEE-guided LAAC, the overcompression group was independently associated to a higher rate of LAA occlusion at TEE follow-up.
Study context
- Population
- Consecutive patients undergoing transesophageal echocardiography (TEE)-guided LAAC with Watchman FLX in 2 high-volume centres, 2020–2023
- Participants
- 61 vs 175
- Exposure
- Watchman FLX overcompression vs normal compression
- Overcompressionn = 61
- Normal compressionn = 175reference
- Outcome
- Residual peridevice leak (PDL) at TEE follow-up
- Follow-up
- 2 months
Methodological detailsdual-centre, consecutive patients
- Dual-centre
- Consecutive patients
Main finding
As reported in the abstract
Residual PDL · 2-month TEE follow-up
P < 0.001
Observational data: associations, not effects.
Further findings
PDL at TEE follow-up, multivariate analysis (device compression rate)
- Device compression rate the only variable independently associated with PDL risk (adjusted OR 0.935; 95% CI 0.927-0.948)
- P = 0.003
CV death, ischemic stroke or systemic embolism · during follow-up
- Not significantly different between groups (overcompression vs normal compression: 9.8% vs 12%)
- P = 0.971
Safety
Procedural complications (composite)
- Not significantly different between groups (overcompression vs normal compression: 1.6% vs 1.7%)
- P = 0.968
Original publication
Impact of Device Compression on Peridevice Leak After Left Atrial Appendage Closure: The Impression LAAC Study. JACC Clin Electrophysiol. Published 2 October 2025. doi:10.
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