Valvular & structural heart disease
Left Ventricular Hypertrophy as a Predictor of Cardiovascular Outcomes After Transcatheter Aortic Valve Replacement
Authors' conclusion
Severe LVH before TAVR is a prognostic factor for poor post-operative cardiovascular outcomes. LVH associated with aortic stenosis and CSN function are correlated, suggesting their involvement in LVH prognosis.
Study context
- Population
- Patients with severe AS who underwent transcatheter aortic valve replacement (TAVR), July 2017–May 2020
- Participants
- 349 patients
- Exposure
- Severe left ventricular hypertrophy (LVH) vs no LVH before TAVR
- Outcome
- Freedom from CV events (CV death and HF hospitalization)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Event-free rate
P = 0.021
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Delay H/M (123I-MIBG), pre-TAVRSevere LVH (+) vs Severe LVH (-) | Severe LVH (+) 2.33 (range 1.92–2.67) · Severe LVH (-) 2.67 (range 2.17–3.68) | P < 0.001 |
| Event-free rate by delay H/MDelay H/M < 2.50 vs Other patients · log-rank | Delay H/M < 2.50 87.7% · Other patients 97.2% | P = 0.012 |
| LVMi · 6 months after TAVRSevere LVH (+) vs Severe LVH (-) | Severe LVH (+) 115 (range 99–130) g/m² · Severe LVH (-) 90 (range 78–111) g/m² | P < 0.001 |
| Delay H/M · 6 months after TAVRSevere LVH (+) vs Severe LVH (-) | Severe LVH (+) 2.53 (range 1.98–2.83) · Severe LVH (-) 2.71 (range 2.25–3.19) | P = 0.025 |
Change in delay H/M by LVH improvement at 6 months · 6 months after TAVR
- Improved LVH: delay H/M from 2.51 [2.01-2.81] to 2.67 [2.26-3.02]
- P < 0.001
- No improved LVH: delay H/M from 2.64 [2.23-3.06] to 2.53 [1.97-3.00], no significant change
- P = 0.829
Original publication
Left Ventricular Hypertrophy as a Predictor of Cardiovascular Outcomes After Transcatheter Aortic Valve Replacement. ESC Heart Fail. Published 1 February 2023. doi:10.
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