Lipoprotein(a) is associated with a larger systemic burden of arterial calcification
Authors' conclusion
Higher Lp(a) was consistently associated with a larger calcification burden in all major arteries.
Study context
- Population
- Rotterdam study participants (mean age 69.5 years, 52.3% women) undergoing non-contrast CT
- Participants
- 2,354 participants
- Exposure
- Higher vs lower plasma Lp levels
- Outcome
- Ln-transformed calcification volumes of coronary artery (CAC), aortic arch (AAC), extracranial (ECAC) and intracranial carotid artery (ICAC); severe calcification (upper quartile of volume)
Methodological detailscross-sectional analysis, sex-stratified multivariable linear and logistic regression
- Cross-sectional analysis
- Sex-stratified multivariable linear and logistic regression
Main finding
As reported in the abstract
Ln-transformed calcification volume per 1 SD higher Lp(a) (fully adjusted beta)
- Women · coronary artery calcification (CAC)
- beta per 1 SD 0.09 (95% CI 0.04–0.14)
- Men · CAC
- beta per 1 SD 0.09 (95% CI 0.03–0.14)
- Women · aortic arch calcification (AAC)
- beta per 1 SD 0.06 (95% CI 0.01–0.11)
- Men · AAC
- beta per 1 SD 0.09 (95% CI 0.03–0.14)
- Women · ECAC
- beta per 1 SD 0.07 (95% CI 0.02–0.13)
- Men · ECAC
- beta per 1 SD 0.08 (95% CI 0.03–0.14)
- Women · intracranial carotid artery calcification (ICAC)
- beta per 1 SD 0.09 (95% CI 0.03–0.14)
- Men · ICAC
- beta per 1 SD 0.05 (95% CI −0.02 to 0.11)
Observational data: associations, not effects.
Further findings
Severe calcification (upper quartile), highest Lp(a) percentile
| OR (95% CI) | ||
|---|---|---|
| WomenSevere ICAC (most prevalent in women) · fully adjusted | 2.41 (1.25–4.63) | |
| MenSevere AAC (most prevalent in men) · fully adjusted | 3.29 (1.67–6.49) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Lipoprotein(a) is associated with a larger systemic burden of arterial calcification. Eur Heart J Cardiovasc Imaging. Published 22 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →