Acute cardiac care & resuscitation
Mild induced hypothermia in patients with infarct-related cardiogenic shock and cardiac arrest: insights from the CULPRIT-SHOCK trial
Authors' conclusion
In this retrospective analysis MIH was not significantly associated with lower 1-year mortality in patients with infarct-related CS and CA. Because of the numerically lower mortality rate, further research is necessary to clarify the role of MIH in this patient population.
Study context
- Population
- Patients with infarct-related cardiogenic shock (CS) and cardiac arrest (CA)patients with CA, 288 (52.4%) received mild induced hypothermia (MIH)
- Participants
- 550 patients
- Exposure
- Patients with infarct-related CS and CA who received MIH vs. those who did not
- MIHn = 288
- Outcome
- 1-year mortality
- Follow-up
- 1 year
Methodological detailsrandomized CULPRIT-SHOCK trial and the accompanying registry
- Randomized CULPRIT-SHOCK trial and the accompanying registry
Main finding
As reported in the abstract
MIH vs No MIHHazard ratio (95% CI)P value
Unadjusted; favoured MIH
0.77(0.61–0.97)
P = 0.024After multivariate adjustment; not statistically significant
0.83(0.64–1.09)
P = 0.18Observational data: associations, not effects.
Secondary outcomes
Need for renal replacement therapy
Use of mechanical circulatory support
Baseline characteristics
Age MIH 64 years · No MIH 67 years
Mechanical ventilation
Mean arterial pressure MIH 82 mmHg · No MIH 76 mmHg
- Need for renal replacement therapy: P = 0.005
- Use of mechanical circulatory support: P < 0.001
- Baseline characteristics: Age P = 0.03
- Baseline characteristics: Mechanical ventilation P < 0.01
- Baseline characteristics: Mean arterial pressure P = 0.002
Original publication
Mild induced hypothermia in patients with infarct-related cardiogenic shock and cardiac arrest: insights from the CULPRIT-SHOCK trial. Eur Heart J Acute Cardiovasc Care. Published 23 September 2025. doi:10.
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