Modeling of the Tricuspid Valve and Right Ventricle in Hypoplastic Left Heart Syndrome With a Fontan Circulation
Authors' conclusion
Moderate or greater TR in patients with hypoplastic left heart syndrome with a Fontan circulation is associated with greater leaflet billow volume, a more laterally directed anterior papillary muscle angle, and greater annular distance between the anteroseptal commissure and anteroposterior commissure. However, there is significant heterogeneity of structure in the TV leaflets in regurgitant valves.
Study context
- Population
- Patients with hypoplastic left heart syndrome and a Fontan circulation
- Participants
- 100 patients
- Exposure
- Moderate or greater tricuspid regurgitation (TR) vs mild or less TR
- Outcome
- TV structure associated with moderate or greater TR
Methodological details3D echocardiographic modeling, shape analysis
- 3D echocardiographic modeling
- Shape analysis
Main finding
As reported in the abstract
Univariate: moderate or greater TR had larger tricuspid valve (TV) annular diameters and area, greater anteroseptal–anteroposterior commissure distance, greater leaflet billow volume, more laterally directed anterior papillary muscle angles
P<0.001
Multivariate: greater total billow volume, lower anterior papillary muscle angle, greater anteroposterior–anteroseptal commissure distance associated with moderate or greater TR
P<0.001
Multivariate model C statistic
0.85
Larger RV volumes associated with moderate or greater TR
P<0.001
Observational data: associations, not effects.
Original publication
Summarised from the published abstract; every number is checked against it