Valvular & structural heart disease
Relevance of Residual Tricuspid Regurgitation for Right Ventricular Reverse Remodelling After Tricuspid Valve Intervention in Patients with Severe Tricuspid Regurgitation and Right-Sided Heart Failure
Authors' conclusion
In patients with severe TR and right-sided heart failure undergoing TTVI, superior procedural results were associated with more pronounced RVRR.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) and right-sided HF treated with transcatheter tricuspid valve intervention (TTVI) (T-TEER, transcatheter annuloplasty, orthotopic or heterotopic TTVR)
- Participants
- 253 patients
- Exposure
- Residual TR ≤1+ vs 2+ vs ≥2+ after TTVI
- Outcome
- RVRR (3D echocardiography and cardiac magnetic resonance (CMR))
- Follow-up
- 30 days after the procedure
Methodological detailsfour sites, two independent validation cohorts
- Four sites
- Two independent validation cohorts
Main finding
As reported in the abstract
RVRR · 30 days
- Residual TR ≤1+: pronounced reduction of RV end-diastolic and end-systolic volumes
- Residual TR ≥2+: Right ventricular reverse remodelling (RVRR) effect gradually decreased with higher residual TR
- Findings validated in two independent cohorts
Observational data: associations, not effects.
Further findings
1-year survival
- Residual TR ≤1+ and 2+ associated with similar 1-year survival
RVRR by treatment modality
- RVRR only after T-TEER or orthotopic TTVR, not after heterotopic TTVR
Decongestion and functional improvement · 30 days
- Significant decongestion and functional improvement with all three treatment modalities
Original publication
Relevance of Residual Tricuspid Regurgitation for Right Ventricular Reverse Remodelling After Tricuspid Valve Intervention in Patients with Severe Tricuspid Regurgitation and Right-Sided Heart Failure. Eur J Heart Fail. Published 26 November 2024. doi:10.
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