Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial
Primary result · SBPResult — go to the resultDifference −7.1 mmHg 95% CI −10.5 to −3.8Authors' conclusion
The results of this trial indicate that use of salt substitute, but not efforts to restrict salt supply, may achieve blood pressure lowering and deliver health benefits to residents of elderly care facilities in China.
Study context
- Population
- Adults aged 55 years or older in 48 residential elderly care facilities in China48 facilities
- Participants
- 1,612 adults
- Comparison
- Salt substitute vs usual salt; restricted vs usual supply of salt or salt substitute
- Primary endpoint
- Systolic blood pressure
Methodological details2 × 2 factorial
- 2 × 2 factorial
Primary result
SBP
Difference
−7.1 mmHg
95% CI −10.5 to −3.8
Salt substitutevs Usual salt
difference −7.1 mmHg (95% CI −10.5 to −3.8)
As reported in the abstract
Further findings
| Outcome | Difference (mmHg) (95% CI) | |
|---|---|---|
| DBPSalt substitutevs Usual salt | −1.9 (−3.6 to −0.2) | |
| −4−202Difference, mmHg (linear scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| CV eventsSalt substitutevs Usual salt | 0.60 (0.38–0.96) | |
| Total mortalitySalt substitutevs Usual salt | 0.84 (0.63–1.13) | |
| 0.20.5125Hazard ratio (log scale) |
Salt restriction, all outcomes
- Salt restriction had no effect on any study outcome
Original publication
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial. Nat Med. Published 13 April 2023. doi:10.
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