Effect of a Salt Substitute on Incidence of Hypertension and Hypotension Among Normotensive Adults
Primary result · Hypertension incidenceResult — go to the resultAdjusted hazard ratio 0.60 95% CI 0.39–0.92Authors' conclusion
In Chinese older adults with normal blood pressure, replacing usual salt with a salt substitute may reduce the incidence of hypertension without increasing hypotension episodes.
Study context
- Population
- Chinese older adults with normal BP in elderly care facilities
- Participants
- 313 vs 298
- Comparison
- Salt substitute vs usual salt
- Salt substituten = 313
- Usual saltn = 298reference
- Primary endpoint
- Incident hypertension
- Follow-up
- 2 years
Methodological detailspost hoc analysis, cluster-randomised, multicentre, 48 elderly care facilities
- Post hoc analysis
- Cluster-randomised
- Multicentre
- 48 elderly care facilities
Primary result
Hypertension incidence
Adjusted hazard ratio
0.60
95% CI 0.39–0.92
P = 0.02
By group
Salt substitute
11.7 per 100 person-years
Usual salt
24.3 per 100 person-years
Salt substitutevs Usual salt
adjusted HR 0.60 (95% CI 0.39–0.92); P = 0.02
As reported in the abstract
Further findings
Mean change, mm Hg
| Outcome | Salt substitute | Usual salt | Net reduction (mm Hg) (95% CI) | |
|---|---|---|---|---|
| SBP change from baseline to end of intervention | −0.3 (SD 11.9) | 7.0 (SD 14.3) | −8.0 (−12.4 to −3.7) | |
| DBP change from baseline to end of intervention | 0.2 (SD 7.1) | 2.1 (SD 7.5) | −2.0 (−4.1 to 0.1) | |
| −15−10−505Difference, mm Hg (linear scale) |
Safety
Per 100 person-years
| Outcome | Salt substitute | Usual salt | P value |
|---|---|---|---|
| Hypotension episodes | 9.0 | 9.7 | P = 0.76 |
Original publication
Effect of a Salt Substitute on Incidence of Hypertension and Hypotension Among Normotensive Adults. J Am Coll Cardiol. Published 20 February 2024. doi:10.
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