Valvular & structural heart disease
Structural and functional abnormalities of left-sided cardiac chambers in Barlow’s disease without significant mitral regurgitation
Authors' conclusion
BD patients without significant MR show early LV and LA remodelling, together with reduced LA strain. MR progression was associated with eccentric LV remodelling, MAD, and MR severity.
Study context
- Population
- Patients with Barlow's disease without significant mitral regurgitation (MR), two tertiary centresmatched 1:1
- Exposure
- Barlow's disease without significant MR vs healthy controls
- Barlow's disease (BD)n = 231
- Outcome
- LV and LA structure and function
Methodological detailstwo tertiary centres, 1:1 matched with healthy controls
- Two tertiary centres
- 1:1 matched with healthy controls
Main finding
As reported in the abstract
- Increased left ventricular (LV) dimensions and LVMi in BD vs controls
- P < 0.001
- Larger left atrial (LA) volumes and more impaired LA reservoir strain in BD vs controls
- P < 0.001
Observational data: associations, not effects.
Further findings
- MR progression to moderate-to-severe or greater (BD)
- 51 · events
- MR progression to moderate-to-severe or greater (BD): 170 patients with available follow-up
MR progression to moderate-to-severe or greater (BD)
- Independent predictors on Cox regression: age, eccentric LV hypertrophy (eLVH), mild-to-moderate MR, MAD
Original publication
Structural and functional abnormalities of left-sided cardiac chambers in Barlow’s disease without significant mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 6 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →