Heart failure & cardiomyopathies
Tricuspid Regurgitation in Elderly Patients with Acute Heart Failure: Insights from the Kyoto Congestive Heart Failure (KCHF) Registry
Authors' conclusion
In a large Japanese AHF population, the grades of TR could successfully stratify the risk of all-cause death. However, the association of TR with mortality was only modest and attenuated in patients aged 80 or more.
Study context
- Population
- Patients hospitalized for acute heart failure (HF) in the Japanese KCHF registry; median age 80 years
- Participants
- 3,735 patients
- Exposure
- Mild, moderate and severe tricuspid regurgitation (TR) vs no TR
- No TRn = 1,205reference
- Mild TRn = 1,537
- Moderate TRn = 776
- Severe TRn = 217
- Outcome
- All-cause death
Methodological detailsmulticentre, TR graded per routine clinical practice at each centre, Median follow-up 475 (IQR 365-653) days; 94.0% follow-up at 1 year
- Multicentre
- TR graded per routine clinical practice at each centre
- Median follow-up 475 (IQR 365-653) days; 94.0% follow-up at 1 year
Main finding
As reported in the abstract
1 year
Each group vs no TRAdjusted hazard ratio (95% CI)P value
Mild TR
1.20(1.00–1.43)
P = 0.0498Moderate TR
1.32(1.07–1.62)
P = 0.009Severe TR
1.35(1.00–1.83)
P = 0.049Observational data: associations, not effects.
Secondary outcomes
| Outcome | No TR | Mild TR | Moderate TR | Severe TR | Adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|---|---|
| Hospitalization for HF · 1 yearMild TRvs No TR | 18.9% | 23.0% | 28.5% | 28.4% | 1.16 (0.97–1.38) | P = 0.10 | |
| Hospitalization for HF · 1 yearModerate TRvs No TR | 1.19 (0.96–1.46) | P = 0.11 | |||||
| Hospitalization for HF · 1 yearSevere TRvs No TR | 1.20 (0.87–1.65) | P = 0.27 | |||||
| 0.512Adjusted hazard ratio (log scale) |
All-cause death, by age (subgroup)
- Higher adjusted HRs of all TR grades vs no TR significant in patients aged <80 years, not in those aged ≥80 years
- Significant interaction
Surgical intervention for TR within 1 year (moderate/severe TR, n = 993)
- Underwent TR surgery
- 13 (1.3%)
Original publication
Tricuspid Regurgitation in Elderly Patients with Acute Heart Failure: Insights from the KCHF Registry. ESC Heart Fail. Published 29 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →