Coronary disease & ACSCohort study
Coronary Atherosclerosis Phenotypes in Focal and Diffuse Disease
- Prospective cohort study
- multicentre
- single-arm
- 5 countries
Authors' conclusion
Atherosclerotic plaque phenotypes associate with intracoronary hemodynamics. Focal CAD had a higher plaque burden and was predominantly lipid-rich with a high prevalence of TCFA, whereas calcifications were more prevalent in diffuse CAD.
Study context
- Population
- Patients with functionally significant coronary lesions (invasive FFR ≤0.80)
- Participants
- 117 patients · 120 vessels
- Exposure
- Focal vs diffuse coronary artery disease (CAD)
- Outcome
- Atherosclerotic plaque phenotypes by CT angiography and optical coherence tomography
Main finding
As reported in the abstract
Plaque phenotypes Focal mean 87% (SD 8%) · Diffuse mean 82% (SD 10%)
Plaque burden (CT) Focal 87% ± 8% · Diffuse 82% ± 10% · P = 0.003
Agatston score per vessel Focal 51 [IQR: 11-204] · Diffuse 158 [IQR: 52-341] · P = 0.024
Circumferential lipid-rich plaque
P = 0.001
TCFA
P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | AUC (95% CI) |
|---|---|
| Focal disease (PPG) predicting TCFA | 0.73 (0.58–0.87) |
Pullback pressure gradient (PPG) distribution
- Median PPG
- 0.66 (IQR: 0.54-0.75)
Original publication
Summarised from the published abstract; every number is checked against it