Leg strength and incidence of heart failure in patients with acute coronary syndrome
Authors' conclusion
The present study showed that a higher level of QIS was strongly associated with a lower risk of developing HF after ACS.
Study context
- Population
- Patients with acute coronary syndrome (ACS) without prior heart failure (HF) or HF complications during hospitalization; median age 67 (57–74) years
- Participants
- 1,053 patients
- Exposure
- High vs low quadriceps isometric strength
- Outcome
- HF admissions
- Follow-up
- Mean 4.4 ± 3.7 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)
High QISvs Low QISmultivariate adjusted
0.52(0.32–0.87)
QIS per 5% body weight increment
0.87(0.80–0.95)
- HF admissions overall
- 75 (7.1%)
Observational data: associations, not effects.
Further findings
Risk reclassification for HF with quadriceps isometric strength (QIS) added
- Net reclassification improvement
- 0.26 (95% CI 0.002-0.52)
- Integrated discrimination index
- 0.01 (95% CI 0.004-0.02)
Original publication
Leg strength and incidence of heart failure in patients with acute coronary syndrome. Eur J Prev Cardiol. Published 27 December 2023. doi:10.
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